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upstream
01
situated or moving in the direction opposite to the flow of a stream or current
Examples
The upstream hike offers breathtaking views of the valley.
The upstream swim against the current was challenging but invigorating.
02
occurring earlier in a sequence of genetic material where transcription begins before a specified point
Examples
The enzyme regulates an upstream reaction critical to the metabolic pathway.
Upstream signals from the receptor activate downstream transcription factors.
03
happening earlier and setting the stage for subsequent events or outcomes
Examples
Poor planning was an upstream factor in the project's failure.
Addressing upstream causes can improve efficiency later.
