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sadly
01
in a sorrowful or regretful manner
Example
He spoke sadly about the missed opportunities in his career.
She said goodbye sadly.
02
in a manner that is most unfortunate
Example
Sadly, we wo n't be able to attend the wedding due to a prior commitment.
I could n't make it to the concert, sadly, as I was feeling unwell.
03
in a manner that results in regret or disappointment
Example
His plans sadly fell apart due to unforeseen circumstances.
The experiment sadly did not yield the expected results.