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Vicissitude
01
mutability in life or nature (especially successive alternation from one condition to another)
02
the unpredictable changes or fluctuations in circumstances, often involving alternating periods of success and adversity
Example
Throughout his career, he experienced numerous vicissitudes, including both triumphs and setbacks.
Despite the vicissitudes of life, she remained resilient and adaptable, facing challenges with grace and determination.
Amidst the vicissitudes of history, civilizations rise and fall, leaving behind legacies that endure through the ages.
