Immunosuppression refers to the weakening or reduction of the immune system's activity. This can happen naturally, such as in certain medical conditions or with aging, or it can be caused intentionally through medications or treatments. Immunosuppression is often used in medical settings to prevent the rejection of transplanted organs or to manage autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. However, it also increases the chances of infection and may require careful monitoring to balance its benefits and risks.

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