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irreversible
Example
Deforestation on a massive scale may initiate irreversible changes to the local climate and environment.
Smoking can cause irreversible damage to the lungs over many years.
The irreversible consequences of climate change are becoming increasingly apparent.
The irreversible loss of data due to a computer crash could have been prevented with regular backups.
Once a decision is made by the court, it is often irreversible and cannot be easily overturned.
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