Loco disease, also known as locoism, is a condition that mainly affects cattle, sheep, and horses when they consume toxic plants containing certain chemicals. These toxic plants cause neurological damage and behavioral changes in affected animals. Symptoms of loco disease can include uncoordinated movements, muscle tremors, excessive salivation, and changes in behavior like aggression or lack of energy. In serious cases, it can lead to paralysis or death. Prevention involves identifying and removing toxic plants from grazing areas and providing other sources of feed for livestock. Treatment options are limited, and supportive care may be necessary to manage symptoms in affected animals.

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