Charcot-marie-tooth disease (CMT) is a group of inherited neurological disorders that affect the nerves outside the brain and spinal cord, causing muscle weakness and wasting, mainly in the feet and lower legs, but also in the hands in some cases. It is typically characterized by progressive muscle weakness, loss of sensation, and foot deformities. CMT can also cause difficulties with balance and coordination. The condition is caused by changes in genes that affect the structure and function of the nerves outside the brain and spinal cord. Treatment for charcot-marie-tooth disease focuses on managing symptoms and may include physical therapy, orthopedic devices such as braces or orthotic inserts, and in some cases, surgery to correct foot deformities or release compressed nerves.

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