تعریف و معنای "set one's teeth on edge"

What is the origin of the idiom "set one's teeth on edge" and when to use it?

The idiom "set one's teeth on edge" has its origins in biblical scripture, specifically in the Book of Jeremiah in the Old Testament. This idiom is used to convey a visceral reaction, emphasizing the intensity of the negative sensation. It can be used in various scenarios, such as describing the effect of screeching brakes, nails on a chalkboard, certain types of music, extremely bitter or sour flavors, or even certain textures that cause discomfort.