Adrenocorticotrophic hormone (ACTH) is a hormone produced by the anterior pituitary gland. It plays a crucial role in regulating the production and release of cortisol from the adrenal glands. ACTH stimulates the adrenal cortex, which is responsible for producing various hormones, including cortisol. By acting on the adrenal glands, ACTH helps maintain the body's response to stress, regulates blood sugar levels, and supports immune function. ACTH release is controlled by a feedback mechanism involving the hypothalamus and the adrenal glands, ensuring the proper balance of cortisol in the body.

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